Prenatal exposure to persistent organic pollutants and rapid weight gain and overweight in infancy.

Prenatal Organochlorine Compound Exposure, Rapid Weight Gain, and Overweight in Infancy

BACKGROUND Although it has been hypothesized that fetal exposure to endocrine-disrupting chemicals may increase obesity risk, empirical data are limited, and it is uncertain how early in life any effects may begin. OBJECTIVES We explored whether prenatal exposure to several organochlorine compounds (OCs) is associated with rapid growth in the first 6 months of life and body mass index (BMI) l...

Author’s response to reviews Title: Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: a prospective cohort study Authors:

Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: a prospective cohort study

BACKGROUND Prenatal exposure to persistent organic pollutants (POPs), may influence offspring weight gain. More prospective epidemiological studies are needed to compliment the growing body of evidence from animal studies. METHODS Serum from 412 pregnant Norwegian and Swedish women participating in a Scandinavian prospective cohort study were collected in 1986-88, and analyses of two perfluor...

Associations between Exposure to Persistent Organic Pollutants in Childhood and Overweight up to 12 Years Later in a Low Exposed Danish Population

BACKGROUND Persistent organic pollutants (POPs) have metabolic disrupting abilities and are suggested to contribute to the obesity epidemic. We investigated whether serum concentrations of POPs at 8-10 years of age were associated with subsequent development of overweight at age 14-16 and 20-22 years. METHODS The study was based on data from the European Youth Heart Study, Danish component (1...

Association of Prenatal Exposure to Persistent Organic Pollutants with Obesity and Cardiometabolic Traits in Early Childhood: The Rhea Mother–Child Cohort (Crete, Greece)Rhea Mother–Child Cohort (Crete, Greece)

Introduction Persistent organic pollutants (POPs) are ubiquitous and persist in the environment, accumulate in high concentrations in fatty tissues, and are biomagnified through the food chain. POPs include synthetic chemicals that were widely used as pesticides [e.g., dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethylene (DDE), hexachlorobenzene (HCB)] and in industrial proce...